Naïve patients receiving TDF/FTC-EFV as 2 pills are more likely to modify regimen components than patients receiving a TDF/FTC/EFV single pill

Results From Jan/06 to Dec/09, 136 patients started HAART with TDF, FTC & EFV as 1p (59, 42.8%) or 2p (79, 57.2%). Mean age: 38.5 (1p) and 38.6 (2p), 83.1% male (1p) and 75.3% (2p). Median CD4: 250 (1p) and 244 (2p), mean viral load (log): 4.53 (1p) and 4.48 (2p), HCV coinfected: 15.3% (1p) and 19.5% (2p). One-year probability of HAART modification was 14.7% (95%CI 9.7-21.6) globally, 20.78% (13.22-31.12) for 2p and 6.7% (2.67-16.18) for 1p. Proportions of patients with viral load <50 copies/mL after one year of follow up were 87.5% (1p) and 94.4% (2p). Reasons for HAART modification were toxicity (8.7%) and lack of efficacy (2.2%) or adherence (3.6%). HAART modification due to toxicity was more frequent (7.52%) with 2p (5 skin rashes, 2 SNC adverse events, 1 impairment of renal function and 1 osteopenia) than with 1p (2 skin rashes, 1.5%). Patients on 2p were changed to TDF/FTC + LPV/r (3), TDF/FTC + ATV/r (2), TDF/FTC + NVP (1), ABC/3TC + EFV (2), ABC/3TC + LPV/r (1), ABC/3TC + ATV/r (1), AZT/3TC/ABC + TDF (1) or stopped treatment (5). Patients on 1p switched to TDF/FTC + LPV/r (1), TDF/FTC + DRV/r (1) or stopped treatment (2). Multivariant logistic regression analysis showed that a 2p regimen [OR 5.0 (1.18-21.16)], prior AIDS-defining condition [4.09 (1.37-12.27)] and time (months) since HIV diagnosis [1.015 (1.006-1.025)] were significantly associated to HAART modification.